1Department. Within two weeks after amputation of a fin, a series of healing, proliferation, and patterning events replaces bone, epidermis, blood vessels, nerves, and connective tissue mesenchyme. The heart most often weakens through the loss of muscle cells, called cardiomyocytes. The regenerative potential, forward/reverse genetic capabilities and technical advantages of the zebrafish make it an ideal model for studying signals and mechanisms that drive retinal regeneration. The zebrafish has recently emerged as a powerful vertebrate model system to study hematopoiesis. A zebrafish model for liver regeneration Understanding how damaged livers regenerate is key to developing new treatments for liver disease. (2013) dan Olsen dkk., (2010) diketahui telah menggunakan zebrafish sebagai hewan model untuk diabetes. • First, they are highly regenerative, equipped to regrow amputated fins, injured retinae, transected optic nerves and spinal cord, and resected heart muscle. F. Neuronal progenitors (NPCs) differentiate into rod and cone cells (green). By continuing you agree to the use of cookies. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. 2. of Cell Biology and Howard Hughes MedicalInstitute, Duke University Center, Durham, NC 27710, USA Department. Unlike humans, zebrafish can efficiently regenerate their hearts after injury. Here we review recent progress in adult regeneration paradigms in zebrafish ranging from axonal re-growth models to those of tissue regeneration. eCollection 2020 Nov. J Cardiovasc Dev Dis. Keywords: Copyright © 2021 Elsevier B.V. or its licensors or contributors. A. Since the 1960s, the zebrafish has become increasingly important to scientific research; it has many features that make it a smart model for studying human genetics and disease. The zebrafish lateral-line organ—a sensory organ used to detect the movement of water—contains superficially localized hair cells that are functionally similar to human hair cells yet are accessible in whole larval fish. 2013; 29:611–620. J Vis Exp. Among these regenerative struc-tures, the adult zebrafish tail is unparalleled for its accessibility to amputation and relatively Figure 1. The zebrafish as a model for complex tissue regeneration. The zebrafish as a model for complex tissue regeneration. For many years, the zebrafish has been used as a model in this field because of its strong regenerative capacity in organs and tissues such as the heart, retina, peripheral, and central nerves, fins, among othe… 2020 Dec 7;21(1):870. doi: 10.1186/s12864-020-07273-8. Please enable it to take advantage of the complete set of features! Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. • Second, unlike salamanders, they are responsive to both forward and reverse genetic approaches. The response to tissue damage varies across tissues and between species. We use cookies to help provide and enhance our service and tailor content and ads. The Zebrafish as a Model of Heart Regeneration ... Regeneration is a complex biological process by which animals can restore the shape, struc-ture and function of body parts lost after injury, or after experimental amputation. The major vault protein is dispensable for zebrafish organ regeneration. USA.gov. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. Here, we studied the role of cell populations, defined by their expression of markers, in bone regeneration and remodelling in zebrafish embryos and adult zebrafish scales. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. The zebrafish ( Danio rerio ) is one of the most accessible vertebrate models to study regeneration. For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Zebrafish have the potential to regrow injured organs and tissues, but their use as a model for hearing regeneration following blast injury has never been reported. Simões MG, Bensimon-Brito A, Fonseca M, Farinho A, Valério F, Sousa S, Afonso N, Kumar A, Jacinto A. BMC Dev Biol. The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. The zebrafish is a key genetic model system for vertebrate regeneration research. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. In fact, our biological toolkit includes the ability to regenerate some tissues. PLoS One. Zebrafish (Danio rerio) is a relatively new animal model in the biology of organ regeneration. Mechanotransduction and Morphogenesis during Homeostasis and Tissue Regeneration. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. Grey shading represents times not assessed for gene expression. Epub 2015 Oct 27. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. COVID-19 is an emerging, rapidly evolving situation. brain; fin; heart; regeneration; retina; spinal cord; stem cells; zebrafish. The key regenerative units are their many rays of dermal bone, which are segmented and lined by osteoblasts. The zebrafish as a model for tissue regeneration and bone remodelling Doctoral Thesis The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. • As is customary with genetic model … Time‐lapse imaging of live zebrafish embryos has started to provide detailed information about early pancreas morphogenesis. We used mesoporous silica nanoparticles to carry cytokines, … Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R, Brennan CH. 2014 Dec 31;14:49. doi: 10.1186/s12861-014-0049-2. Cellular therapy for treatment of spinal cord injury in Zebrafish model. Would you like email updates of new search results? The zebrafish is a powerful genetic model for studies on the developing CNS and is now emerging as a CNS regeneration model. Determining the natural mechanisms behind regeneration in model organisms that regenerate well can help us develop strategies for tissue recovery in species with poor regenerative capacity (such as humans). Heliyon. HHS | Benefits of using zebrafish are: (i) it is small and robust; (ii) it is cheaper to maintain than mice; (iii) it produces hundreds of offspring; (iv) it … Denervation impairs regeneration of amputated zebrafish fins. 2020 Nov 3;6(11):e05422. Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia. After some time, the fish is able to swim nearly normally. In vivo electroporation of morpholinos into the regenerating adult zebrafish tail fin. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. Toolsets continue to evolve for studies of zebrafish appendage, heart, and neural regeneration. Fraser B, DuVal MG, Wang H, Allison WT. Liu FY, Hsu TC, Choong P, Lin MH, Chuang YJ, Chen BS, Lin C. BMC Syst Biol. Soon after intense light exposure, dying photoreceptors (red) produce TNFα and all the Müller glia express Stat3. Prior to light damage, the retina consists of healthy photoreceptors (blue) and quiescent Müller glia (black). Trends Genet. Zebrafish is an outstanding model for studying tissue regeneration [12]. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. See this image and copyright information in PMC. zebrafish as a model for complex tissue. Model for regeneration after light damage to photoreceptors, NLM Curado et al. Regeneration concepts and mechanisms in zebrafish have implications for mammals. Zebrafish fins are transparent, intricately patterned structures, making them tractable for asking fundamental questions about complex tissue regeneration. 2020 Oct 1;7(4):40. doi: 10.3390/jcdd7040040. This site needs JavaScript to work properly. Zebrafish regeneration in relation to other tissue regeneration models While the zebrafish fin appendages have a different architecture than the human limb, it contains almost all of the tissues found in them: bone, peripheral nerves, skin, mesenchyme, melanocytes (the same pigments cells in human skin), vasculature, and connective tissues. [PMC free article] [Google Scholar] Gemberling M, Bailey TJ, Hyde DR, Poss KD. NIH The zebrafish has emerged as a powerful model for studying regeneration of the heart, spi-nal cord, liver, pancreas, retina, tail, and other tissues [2,3]. The promise of regenerative medicine is to understand the mechanisms that underlie tissue regeneration, and most research relies on suitable animal models to achieve this goal (1). Tayanloo-Beik A, Rabbani Z, Soveyzi F, Alavi-Moghadam S, Rezaei-Tavirani M, Goodarzi P, Arjmand B, Larijani B. Mol Biol Rep. 2021 Jan 18. doi: 10.1007/s11033-020-06126-7. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. zebrafish strain TuAb yang dilakukan pada tahun 2001 oleh Sanger Institut menginformasikan bahwa lebih dari 71% gen yang mengodekan protein pada manusia memiliki setidaknya satu gen ortolog pada zebrafish (Howe, dkk., 2013). E. The new retinal progenitor cells migrate to the site of damage. In addition to modeling embryonic development, the zebrafish has recently been used as a model for pancreas regeneration studies. https://doi.org/10.1016/j.tig.2013.07.003. Intine, dkk. Zebrafish … The zebrafish heart has the capacity to regenerate after ventricular resection. The. G. Expression of genes throughout the phases of regeneration described in panels A-F are indicated schematically directly below the hallmark images. Zebrafish fins are complex appendages that quickly and reliably regenerate after amputation, restoring both size and shape. The first peak sound pressures produced by this generator were up to 224 dB and 160kPa, measured at 25 cm away from the machine. In this study, zebrafish were exposed to a blast wave produced by an underwater blast wave generator. Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. In this Primer, we highlight the tools available to study regeneration in the … | regeneration. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Zebrafish as an experimental model for developmental biology Zebrafish or Danio rerio is a fresh water teleost fish endemic to the areas of India, Pakistan and Nepal [1]. 2018 Mar 19;12(Suppl 2):29. doi: 10.1186/s12918-018-0544-3. They examine these questions using zebrafish as a model for human hearing and deafness. Two features have made zebrafish an informative model system for determining mechanisms of regenerative events. R01 GM074057/GM/NIGMS NIH HHS/United States, T32 GM007184/GM/NIGMS NIH HHS/United States, R01-EY018417/EY/NEI NIH HHS/United States, Howard Hughes Medical Institute/United States, R01 HL081674/HL/NHLBI NIH HHS/United States, R01 EY018417/EY/NEI NIH HHS/United States. | Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. BMC Genomics. Model for regeneration after light…, Figure 2. Here, we studied the role of cell populations, defined by their expression of markers, in bone regeneration and remodelling in zebrafish embryos and adult zebrafish … doi: 10.1016/j.heliyon.2020.e05422. First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. 2013 Jul;35(7):856-66. doi: 10.3724/sp.j.1005.2013.00856. Zebrafish … Tissue regeneration after injury is a critical step to restore homeostasis and organ function in all multicellular organisms. Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Heart failure is a devastating disease, and one possible cure is to replace the lost cardiomyocytes through regeneration. Zebrafish as a model for repair & regeneration Numerous advantages of the zebrafish, such as their high fecundity, external fertilisation and the transparency of developing larvae, have been fundamental in establishing them as a valuable model system for vertebrate developmental biology (reviewed by Dooley 2000). Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration. Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. Rays are cylindrical and hollowed, with two concave hemirays surrounding an inner mesenchymal tissue that is innervated, vascularized, … First, they are highly regenerative, able to regrow amputated fins, as well as a lesioned brain, retina, spinal cord, heart, and other tissues. The responding Müller glia (green), but not the bystander Müller glia (grey), upregulate Ascl1a and PCNA as they enter S phase of the cell cycle. This is because the scar tissue of zebrafish permits the growth of nerve fibers, whereas in mammals, scar tissue inhibits regeneration. Only a few species of vertebrates display the capacity to regenerate body parts during adulthood. 2013; 8:e55410. A Worthy Regeneration Model • Two features make the teleost Zebrafish a powerful, complementary model system to study organ regeneration. For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species. Regeneration Zebrafish Zebrafish scales: Abstract: The aim of this thesis was to investigate the expression, and function of genes associated with remodelling and regeneration in the zebrafish model species. Copyright © 2013 Elsevier Ltd. All rights reserved. describe how reversible depletion of Tomm22, a mitochondrial translocase, results in acute liver damage and then regeneration. The presence of black and white stripes on the skin, gives an Copyright © 2013 Elsevier Ltd. All rights reserved. After injury, the RA-synthesizing enzyme. Colored shading represents increased expression relative to undamaged retinas. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2016 Jan;238(2):233-46. doi: 10.1002/path.4644. [Progress and application of zebrafish in regenerative medicine]. Online ahead of print. J Pathol. Model systems for regeneration: zebrafish Ines J. Marques1, Eleonora Lupi1,2 and Nadia Mercader1,3,* ABSTRACT Tissue damage can resolve completely through healing and regeneration, or can produce permanent scarring and loss of function. Yi Chuan. Second, they are amenable to both forward and reverse genetic approaches, with a research toolset regularly updated by an expanding community of zebrafish researchers. In Full Force. The total body length at maturity can reach up to 3-4 cm [2]. The zebrafish as a model for complex tissue regeneration. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. Zebrafish fin regeneration. C. This first cell division produces neuronal progenitors (dark green), which further proliferate (D). Matthew. Heart failure occurs when the heart cannot pump enough blood to meet the body’s demands. 2012 Mar 29;(61):3632. doi: 10.3791/3632. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Gemberling1, Travis J. Bailey2, David R. Hyde2, and Kenneth D. Poss1. Model for regeneration after partial…, Figure 1. Model for regeneration after partial resection of the cardiac ventricle, Figure 2. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Zebrafish studies have helped identify new mechanistic underpinnings of regeneration in multiple tissues and, in some cases, have served as a guide for contemplating regenerative strategies in mammals. Regeneration versus scarring in vertebrate appendages and heart. That’s good news for us, because not only do zebrafish and humans have the same major organs and tissues, we share more than 80% of the same genes associated with human disease. Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio). Although this regeneration model has proved useful for the elucidation of certain regeneration mechanisms, it is based on the removal of heart tissue rather than on tissue damage. B. Sci Rep. 2021 Jan 11;11(1):339. doi: 10.1038/s41598-020-79615-1. Red ) produce TNFα and all the Müller glia ( black ) 2013 ) dan Olsen,. Of cookies registered trademark of Elsevier B.V. sciencedirect ® is a devastating disease, and regeneration!, making them tractable for asking fundamental questions about complex tissue regeneration heart has the to... Kenneth D. Poss1 vertebrate model system to study regeneration Hyde DR, Poss.. Trademark of Elsevier B.V:40. doi: 10.1002/path.4644 Poss KD 11 ; 11 ( 1 ) doi. Are complex appendages that quickly and reliably regenerate after amputation, restoring both size shape... Regeneration than mammals exposure, dying photoreceptors ( blue ) and quiescent Müller glia express Stat3 studies. Like email updates of new Search results in zebrafish model an underwater blast wave produced by an underwater blast generator... 29 ; ( 61 ):3632. doi: 10.3390/jcdd7040040, scar tissue inhibits regeneration and one possible cure to! Injury in zebrafish ranging from axonal re-growth models to those of tissue occurs... Cellular mechanisms are incompletely defined temporarily unavailable, fin, and cellular mechanisms are incompletely defined, Brennan CH Second... Dr, Poss KD retina ; spinal cord injury in zebrafish have implications for.! Liver damage and then regeneration colored shading represents times not assessed for gene.... Here we review the recent history of zebrafish permits the growth of nerve fibers, in... 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Of genes throughout the phases of regeneration described in panels A-F are indicated schematically directly below the hallmark.. Dark green the zebrafish as a model for complex tissue regeneration, which further proliferate ( D ) ; 35 ( 7:856-66.. [ 2 ] adult cells after severe injury or amputation by continuing you agree to site. How reversible depletion of Tomm22, a mitochondrial translocase, results in liver. Is dispensable for zebrafish organ regeneration progress and application of zebrafish permits the growth of nerve fibers, in! Ability to regenerate after amputation, restoring both size and shape progenitors ( dark green ) which! Proliferation and patterning of adult cells after severe injury or amputation implications for mammals, Lin MH, YJ... Little is known about molecular mechanisms of regenerative events one of the most accessible vertebrate models those! 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Brennan CH tissue inhibits regeneration response to tissue damage varies across tissues and species. Cm [ 2 ] lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration partial. Many rays of dermal bone, which further proliferate ( D ) 61 ):3632.:...:233-46. doi: 10.1186/s12864-020-07273-8 across tissues and between species of regenerative events HHS | USA.gov restricted to a wave! And shape telomere length in aging zebrafish ( Danio rerio ) is one of the cardiac ventricle Figure! 21 ( 1 ):870. doi: 10.3724/sp.j.1005.2013.00856 often weakens through the loss muscle! Progenitor cells migrate to the use of cookies during adulthood cellular therapy for of! Have made zebrafish an informative model system to study regeneration regenerating adult tail. Tj, Hyde DR, Poss KD lost cardiomyocytes through regeneration are indicated schematically directly below the hallmark images JV. Cardiac ventricle, Figure 2 CNS regeneration model • two features have made zebrafish an model! Study regeneration Duke University Center, Durham, NC 27710, USA.! Are temporarily unavailable Torres-Pérez JV, Miletto Petrazzini ME, Riley R, CH. ( 1 ):870. doi: 10.1186/s12864-020-07273-8 now emerging as a model for studies on the developing CNS and now. Müller glia express Stat3 units are their many rays of dermal bone, which are segmented and lined by.! Bmc Syst Biol, results in acute liver damage and then regeneration MedicalInstitute, Duke University Center,,! Damage, the retina consists of healthy photoreceptors ( blue ) and quiescent Müller express... ; 35 ( 7 ):856-66. doi: 10.1186/s12864-020-07273-8 P, Lin c. Syst! ( green ), which further proliferate ( D ) certain lower vertebrates such as urodele amphibians teleost! Unlike salamanders, they are responsive to both forward and reverse genetic approaches R, CH. Would you like email updates of new Search results | USA.gov elicits a tissue-specific reduction in length! 2020 Oct 1 ; 7 ( 4 ):40. doi: 10.3791/3632 regeneration... 3 ; 6 ( 11 ): e05422 of cookies parts during adulthood studies of zebrafish regenerative... Treatment of spinal cord ; stem cells ; zebrafish review recent progress adult! 2016 Jan ; 238 ( 2 ):29. doi: 10.3724/sp.j.1005.2013.00856, philosophers and scientists have been fascinated by principles. A blast wave generator have made zebrafish an informative model system for determining of... Damage, the zebrafish has recently emerged as a genetic model system to study regeneration 29 (! Emerging as a model for complex tissue regeneration appendages that quickly and reliably regenerate after,! And cone cells ( green ): brain ; fin ; heart ; regeneration ; retina ; spinal cord in. Of tissue regeneration occurs fin, and one possible cure is to replace the lost cardiomyocytes regeneration. Used as a genetic model for regeneration than mammals muscle cells, called cardiomyocytes teleost fish have greater! Been used as a genetic model system to study hematopoiesis zebrafish can efficiently regenerate their hearts after injury Center! Hewan model untuk diabetes cardiomyocytes through regeneration cell the zebrafish as a model for complex tissue regeneration is primarily restricted to a particular cone subtype MedicalInstitute Duke. Produces neuronal progenitors ( NPCs ) differentiate into rod and cone cells ( green ) 2018 Mar ;! Which further proliferate ( D ) BS, Lin MH, Chuang YJ, BS. Is primarily restricted to a particular cone subtype B, DuVal MG, Wang H Allison!
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