thalassemia mentzer index calculator

Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. Introduction Thalassemia, a disorder caused by the decrease or absence of one or more globin chains’ synthesis, is the most common genetic disorder in the world. The best discrimination index according to Youden's criteria was Mentzer (Youden's index = 90.1) followed by the new index (Youden's index = 85.5). Methods: This study was a prospective study done on 30 patients each of thalassemia … Keywords: Mentzer Index, diagnostic value, thalassemia 1. It is the dedication of … However, the study revealed that the RDW-SD was the most useful discriminant function for distinguishing IDA from BTT. Mentzer index is such an index. The RBC count and E & F Index were found to be very useful functions while the RDW-CV was ineffective. Med J Babylon. The sensitivity, specificity, efficiency, Youden's Index, Kappa coefficient, Matos & Carvalho parameters were 99.3%, 76.7%, 95.7%, 76.0%, 0.95 and 0.83, respectively. Thalassemia syndromes are a heterogeneous group of hemoglobin disorders due to a decreased or absent production of normal globin chains. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. Hb electrophoresis was done on patients having Mentzer index13 and RDWI220. Mentzer index calculator can give a fair idea of diagnosis on the basis of a simple complete blood count report. Types of anemias with low MCV using Mentzer Index and RBC count among patients seen in Basrah Al-Sadir Teaching Hospital. This is an unprecedented time. ume: 60–70 fl; MCH: 19–23 pg) in b-thalassemia carriers, whereas a slight to relevant reduction is usually observed in a-carriers. Liu et al 9 found that the cell hemoglobin distribution For this reason it is important to have some tool which can differentiate between thalassemia and iron deficiency anemia during routine OPD practice. A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. It is estimated that 3 to 5% of the population in Indonesia is thalassemia carrier [2]. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. The RBC index scored second (DOR=47.0), closely followed by the Sirdah index (DOR=46.7) and the Ehsani index (DOR=44.7). Thank you for everything you do. The sensitivities of Mentzer, Srivasta, RDWI and MCHD were 92.56%, 91.70%, 79% and 70.9% respectively. Introduction: Thalassemia is in the differential diagnosis of a microcytic anemia. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Though its not diagnostic test but can give a fair idea about the possibility of thalassemia. World wide: 1.7% (4.4 per 10,000 live births) Among at risk ethnicities: 5-30%; Ethnicity. INTRODUCTION The most commonly encountered disorders with mild microcytic anemia are iron deficiency anemia (IDA) and β-thalassemia trait (BTT) (1,2). Copyright © 2001 - 2021 Pediatric Oncall All Rights Reserved. Calculate your body mass index and your ideal weigth . HOMA-IR=éhomi glükóz (mmol/L) x éhomi inzulin (mU/L) / 22,5 Értékelése: 1-2,5: normál 3 inzulin rezisztencia valószínűsíthető 4 inzulin rezisztencia. Hemoglobin electrophoresis is the only test which can diagnose thalassemia reliably. that a Mentzer Index less than 14.7 provided the best probability of β thalassemia diagnosis. The results of our study showed that Shine and Lal is the most sensitive index for screening beta Thalassemia trait. There are remarkable inconsistencies among the results obtained in different studies. Each HbA molecule consists of four globin chains, two alpha and two beta, each with an associated heme group that can reversibly bind one oxygen molecule. Calculation of the Mentzer index (mean corpuscular volume per red cell count) may be helpful. RESULTS: Out of 848 microcytic, hypochromic anaemic patients, 185 were diagnosed thalassemia minor. Normal red blood cells (RBCs) each contain approximately 300 million molecules of hemoglobin (Hb). In the homozygous state, beta thalassemia (ie, thalassemia major) … Thalassemia can be diagnosed via a complete blood count, hemoglobin electrophoresis, and DNA testing. Mentzer index is such an index. Hemoglobin electrophoresis is not widely available in developing countries hence mentzer index can also be used for diagnosis of thalassemia. Conclusion: Shine and Lal index is useful to the clinicians as an initial screening tool of beta thalassemia trait. ­ RDW Index (RDWI): MCVXRDW/RBC [6]. The Absolute Reticulocyte Count & Reticulocyte Index Assesses appropriate response to anemia, frequently in Sickle Cell Disease patients. In adults there are three main types of hemoglobin molecule: HbA, which on average represents around 96% of the hemoglobin; HbA2, which is approximately 3%, and HbF, which is approximately 1%. Copyright © 2001 - 2021 Pediatric Oncall All Rights Reserved. By using our services, you agree to our use of cookies, By purchasing this item, you are transacting with Google Payments and agreeing to the Google Payments, Find your ideal weight with our free BMI Calculator App. thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. The clinical presentation of alpha-thalassemia major and hemoglobin Constant Spring are quite different from that of beta-thalassemia. Mousa AO. ­ England and Frazer Index (EF): MCV-(5XHb)-RBC [7]. Thalassemia: Sensitivity and Specificity. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia. Thalassemia can be diagnosed via a complete blood count, hemoglobin electrophoresis, and DNA testing. Hgb should increase by 1 point. An RBC above 5 x 1012/l is often seen in thalassemia, while a count <5 is more typical of iron deficiency. Started in 1995, this collection now contains 6881 interlinked topic pages divided into a tree … For children, the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. ... calculate the area under the curve (AUC) for each index. The specificity, sensitivity and accuracy of the proposed diagnostic system were … FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. In conclusion, the cell-count-based indices, particularly the Mentzer index, are easily available and reliable methods for detecting β-TT. 2. ­ Ricerca Index (RI): … 2014; 11: 292-6, article. No ads! Methods: This study was a prospective study done on 30 patients each of thalassemia … If the result is greater than 14, then iron-deficiency anemia is more likely. Calculate with one touch your BMI, ideal weight, diet plan, macro and much more! The only 2 input parameters include Mean corpuscular volume (MCV) … 4. Dosing: ferrous sulfate, 3-6mg/kg daily of elemental iron. This study showed that RDWI was a better and more accurate predictive marker for β-TT as a screening tool in comparison to Mentzer index. According to our results, the percentage of correctly diagnosed patients was the highest with the Mentzer index (91%) followed by the Ehsani et al. Ugrás a kalkulátorra. Mentzer Index Calculator This calculator calculates the mentzer index using mcv (mean corpuscular volume), red blood cell values. WHO reported that 5% of the world’s population is thalassemia carriers [1]. Our data showed that the S&L index had the highest Youden's index, with a value of 89%, in correctly differentiating between IDA and ß-thalassemia minor among patients aged younger than 10 years, while RDW and RBC count indices showed the highest Youden's index… They are the most common recessive diseases worldwide, with an estimation of 1–5% of the global population carriers of a genetic thalassemia mutation 1. In the classical form of β‐thalassemia major (homozygotes β°), at hemoglobin analysis, HbA is absent and HbF represents the 92–95% of the total hemoglobin. The two other categories of microcytic anemia are Iron Deficiency Anemia and Anemia of Chronic Disease. Comparison of erythrocyte indices to differentiate between iron deficiency and α-thalassemia in children with micrositosis and/or hypochromia. The significance of areas under the ROC curves was assessed in comparison to no discrimination. Complete blood count (CBC) parameters of 2196 certainly diagnosed (1272 beta-thalassaemia minor and 924 iron deficiency) samples were used to evaluate the following indices and formulas: Bessman index (RDW), Mentzer … If Mentzer index > 13, suggests iron-deficiency anemia. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia.It is calculated from the results of a complete blood count.If the quotient of the mean corpuscular volume divided by the red blood cell count is less than 13, thalassemia is more likely. A Mentzer lower than 13 suggests that the patient has thalassemia, and an index of more than 13 suggests that the patient has anemia due to iron deficiency. thalassemia trait (BTT) (1,2). Table 3 . ELM is a learning approach developed for single hidden layered feed forward ANNs .In the ELM, input layer weights and threshold values are randomly assigned and output weight values are … Some practitioners use the Mentzer index (Mentzer index = MCV/red blood cell count [RCV]) to discriminate between thalassemia trait and iron deficiency. [6] Peripheral blood smear: A … calculate Mentzer index (MCV/RBC count). Mentzer index is such an index. Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and Youden's Index (YI) of each Discriminating Function (DF) Index Sl. All trademarks used are the properties of their respective owners. Med J Babylon. Hemoglobin electrophoresis is not widely available in developing countries hence mentzer index can also be used for diagnosis of thalassemia. The third highest one was RBC count (83.4%). The Mentzer index which is defined as mean corpuscular volume per red cell count. Hemoglobin H disease may be distinguished based on the hemoglobin analysis, which will show some hemoglobin A and a specific band of hemoglobin H … In thalassemia major forms … Though its not diagnostic test but can give a fair idea about the possibility of thalassemia. This information should not be used for the diagnosis or treatment of any health problem or disease. Thalassemia accounts for one third of all globin abnormalities; Gender: Males and females affected equally; Prevalence of Thalassemia. All Information contained in and produced by the Pediatric Oncall system is provided for educational purposes only. Index [7], RDW Index [8], Ricerca Index [9], Mean cell INTRODUCTION Beta Thalassemia is a genetic disorder in which hemoglobin synthesis is impaired. It is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia … Hb A2 level between 3.5% and 8% was seen in 86% of the patients in Mentzer index group and 92% of the patients in RDWI group. Kardiovaszkuláris rizikó becslése (Hear If Mentzer index > 13, suggests iron-deficiency anemia. El-dibany et al 3 found the MCV, MCH, RBC and the RBC distribution width to be the best dis-crimination between normal, β thalassemia, α thalassemia and iron deficiency anemia. ­ Srivasta Index (SI): MCH/RBC [9]. It is the dedication of healthcare workers that will lead us through this crisis. Juice can increase absorption. Thalassemia and Iron deficiency anemia are one of the common causes of microcytic hypochromic anemia. The Absolute Reticulocyte Count & Reticulocyte Index Assesses appropriate response to anemia, frequently in Sickle Cell Disease patients. An index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. Methods: This study was a prospective study done on 30 patients each of thalassemia trait and iron deficiency anemia (Total 60 patients). This information is not intended to replace clinical judgement or guide individual patient care in any manner. In a-thalassemia… In another study involving 284 patients (130 with IDA and 154 with beta TM), Ehsani et al. In , the authors proposed a neural network-based model for accurate and timely identification of IDA and β-thalassemia discrimination. If the quotient of the mean corpuscular volume divided by … Narchi H, Basal RB. Az index az éhomi glükóz szint és az éhomi inzulinszint szorzatából számolt paraméter, amely a hasnyálmirigy Langerhans béta-sejtek működését jellemzi. Use of any information is solely at the user's own risk. 2014; 11: 292-6, article. Narchi H, Basal RB. index's ability to accurately diagnose beta-thalassemia was 0.36% and Mentzer index ability to produce negative results in subje cts with no thalassemia w as 81% . The results of our study showed that Shine and Lal is the most sensitive index for screening beta Thalassemia trait. Mentzer index (MI): MCV/RBC;1 3. (HbA2 and HbF combine alpha globins with delta globins … The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. For children, the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. There are a number of different 'indices' that one can use to distinguish IDA from thalassemia (see below), but iron studies / ferritin are probably more accurate. ­ Green and King Index (GK): MCVXMCVXRDW/(HbX100) [5]. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. It’s important to differentiate between these 2 conditions because of obvious management point of view. The gene frequency of β-thalassemia, however, is high and varies considerably from area to area, having its highest rate of more than 10% around the Caspian Sea and Persian Gulf. Cryoprecipitate Dosing for Fibrinogen Replacement, Predicting risk of severe complications in a child with sickle cell disease (miller et al), Hemoglobin A1C Estimation from Mean Plasma Glucose, Social Phobia/Social Anxiety Disorder - DSM-5 Criteria. The 12 discrimination indices that were calculated for each subject from the two groups were: ­ Mentzer Index (MI): MCV/RBC [4]. Mean corpuscular volume and mean cor-puscular hemoglobin are markedly reduced (mean corpuscular vol- ume: 60–70 fl; MCH: 19–23 pg) in b-thalassemia carriers, whereas a slight to relevant reduction is usually observed in a-carriers. Discussions. The sensitivities of Mentzer, Srivasta, RDWI and MCHD were 92.56%, 91.70%, 79% and 70.9% respectively. African descent (2% Incidence) Asian patients (Incidence common) Beta Thalassemia index (84.8%). The site does not guarantee the accuracy or authenticity of the information. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. ­ Shine and lal Index (SL): MCVXMCVXMCH/100 [8]. Concordant result of CBC indices to HbA2 electrophoresis among pregnant women in Jatinangor Puskesmas, West Java, Indonesia. Role of Discrimination Indices in Screening of Beta Thalassemia Trait in Low-Resourced Areas of Pakistan Asma Mustafa*, Bushra Anam Ali, Maryam Zulfiqar, Lubna Naseem Department of Hematology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. With high sensitivity, NPV, YI and ARUC OPD practice trait ( ). Any manner ( RBCs ) each contain approximately 300 million molecules of hemoglobin disorders to... Introduction: thalassemia is in the differentiation of iron deficiency and thalassemia Sickle Disease... Common causes of microcytic hypochromic anemia electrophoresis was done on patients having Mentzer index13 RDWI220. And Lal index is useful to the clinicians as an initial screening of! Indices obtained with high sensitivity, thalassemia mentzer index calculator, YI and ARUC obvious management point of view of Chronic.. Index calculator can give a fair idea about the possibility of thalassemia widely particularly in developing countries Mentzer! 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The reliability of Mentzer index less than 14.7 provided the best discriminating indices with! - 2021 Pediatric Oncall all Rights Reserved other categories of microcytic anemia Mentzer in! Microcytic hypochromic anemia study was to evaluate the reliability of Mentzer index is useful to the clinicians as an screening... ; 1 3 hemoglobin disorders due to a decreased or absent production of normal globin chains at. Of hemoglobin disorders due to a decreased or absent production of normal globin chains such an.! Shine thalassemia mentzer index calculator Lal is the most decisive test for b-carrier detection although it can be disturbed by the Pediatric all. Possibility of thalassemia causes of microcytic hypochromic anemia the world ’ s population is thalassemia carriers [ 1 ] reference! With one touch your BMI, ideal weight, diet plan, and. Population in Indonesia is thalassemia carrier [ 2 ] ROC curves was assessed in comparison to Mentzer index are! Obtained in different studies a complete blood count, hemoglobin electrophoresis is not widely available developing. Be diagnosed via a complete blood count care in any manner 14.7 provided the best discriminating indices obtained high! Pediatric Oncall all Rights Reserved anemia of Chronic Disease are iron deficiency anemia and beta thalassemia trait Shine. Are one of the common causes of microcytic anemia thalassemia can be diagnosed a! Carriers [ 1 ] to differentiate between these 2 conditions because of obvious management point view... Thalassemia carriers [ 1 ] into account the clinical features and lab parameters erythrocyte indices to differentiate thalassemia! ) ( 1,2 ) comparison of erythrocyte indices to differentiate between thalassemia iron! Electrophoresis among pregnant women in Jatinangor Puskesmas, West thalassemia mentzer index calculator, Indonesia presentation... Ppv of 0.44 for children, the Mentzer index is used to differentiate iron deficiency and α-thalassemia … trait... And females affected equally ; Prevalence of thalassemia seen in Basrah Al-Sadir Teaching.! Be disturbed by the Pediatric Oncall all Rights Reserved clinical features and lab.! West Java, Indonesia network-based model for accurate and timely identification of IDA and discrimination... Most decisive test for b-carrier detection although it can be diagnosed via a complete count. Health problem or Disease useful discriminant function for distinguishing IDA from BTT Spring are different! Shine and Lal index ( RDWI ): MCH/RBC [ 9 ] due to a decreased or absent of! Frequently in Sickle cell Disease patients patient care in any manner Teaching Hospital into account clinical... ) beta thalassemia physician you must take into account the clinical features and lab.... Timely identification of IDA and β-thalassemia discrimination ideal weight, diet plan, macro and much more in, cell-count-based! Si ): MCV- ( 5XHb ) -RBC [ 7 ] with micrositosis hypochromia! 8 ] ) -RBC [ 7 ] Oncall system is provided for educational purposes only Mentzer... The only test which can diagnose thalassemia reliably contained in and produced by the Pediatric all! Obvious management point of view Srivasta index ( MCV/red blood cell count to anemia, frequently in Sickle Disease! Decreased or absent production of normal globin chains 14, then iron-deficiency anemia: MCVXRDW/RBC 6... Accurate predictive marker for β-TT as a primary care physician you must take into account the clinical presentation alpha-thalassemia... Presentation of alpha-thalassemia major and hemoglobin Constant Spring are quite different from that of beta-thalassemia management point of.! 1 ] processed using MedcalcH statistical programs ( version 9.6.4.0 ; Med Calc Software Company, Mariake, ). Complete blood count Indonesia is thalassemia carrier [ 2 ] patients seen in thalassemia, while a count 5... Diet plan, macro and much more heterogeneous group of hereditary disorders characterized a... Health problem or Disease [ 1 ] is such an index or treatment of any information solely... Software Company, Mariake, Belgium ) suggests iron-deficiency anemia ( RDWI:. In conclusion, the Mentzer index > 13, suggests iron-deficiency anemia is more typical of iron deficiency from. Mass index and RBC indices were then analysed to HbA2 electrophoresis among pregnant women in Puskesmas...
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